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Improved understanding of the mechanisms and intervention strategies for a known risk factor for SUDEP

Sudden Unexpected Death in Epilepsy (SUDEP) can occur in patients with frequent convulsive seizures, with the underlying mechanism thought to be linked to breathing and cardiovascular failure. EEG recordings after seizures have demonstrated a “flattening”, called “postictal generalized EEG suppression”, or PGES. It is not known what the flattening means for the brain and seizure recovery, but this is likely a risk marker for SUDEP. It has been proposed that one contributing factor to SUDEP…