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Research Portfolio

GRANT TITLE:

The link between stress and seizures

GRANT TYPE:

Pilot grant in epilepsy

grant amount:

Amount: £29,208 Duration: 24 months

lead investigator:

Professor Stafford Lightman

Co-Investigators:

institution:

University of Bristol

Background

Why is this research needed? People with epilepsy frequently report emotional stress in the lead-up to a seizure; but although the association between stress and seizures is well recognised, the mechanisms for this is still not understood.

The steroid hormone cortisol is secreted by the body in spurts over the course of the day, and its levels increase dramatically during stress. Cortisol is known to have major effects on both neuronal activity and on the ways that brain cells communicate, so it could plausibly play a role in seizures.

What are the aims? The group plans to discover the part played by cortisol in the generation of seizures.

"If we can understand the mechanisms linking stress and seizures, we should be able to develop means to prevent these seizures.”

The Study

How will the research be carried out? The team will use animal and mathematical models to examine precisely how changes in cortisol levels alter the electrical activity of neuronal circuits in the brain that are known to be associated with seizures. They will later use synthetic compounds that regulate the activity of steroids, to find out whether stress-related seizures can be reduced or even prevented.

Significance

What difference will it make? If successful, this grant could potentially lead to the development of new treatments for epilepsy.