Theme 1:
Neurodevelopment

There is a complex interplay between seizures, cognition, memory and mental health.

People with epilepsy are at increased risk of developing depression and associated anxiety disorders.  For those who are experiencing cognitive and behavioural problems, in most cases, it’s caused by neurodevelopmental disorders such as autism and attention-deficit hyperactivity disorder.

Despite the strong link, we know little about the common underlying causes and how to best treat seizures in autistic people. Epilepsy in autism people is also more likely to be resistant to standard treatments, and it is one of the leading causes of early death among this group.

By increasing our knowledge of the link between epilepsy and neurodevelopmental conditions, and by improving our understanding of the overlap between these disorders, we’ll be able to develop treatments and strategies to prevent, treat and avoid the wider consequences of epilepsy.

Our research priorities

  • Identify mechanisms (processes and interactions) by which the brain becomes susceptible to seizures at different life stages (childhood/adolescence/adult/older age).
  • Harness recent advances in genomics, mechanistic studies, imaging and clinical studies.
  • Identify how and by what mechanisms epilepsy and its treatment impact on learning and cognitive development and ability during childhood.
  • Identify how and by what mechanisms epilepsy and its treatment impact on cognitive ability in adult life.
  • Identify how and by what mechanisms epilepsy and its treatment impact on mental health in children and adults.