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Researcher Directory

Researcher:

Professor Juan Burrone

Theme

institution

Research
Focus

Neuronal circuitry during development, the formation and plasticity of synapses, neurodevelopmental forms of epilepsy, and neurodegeneration.

Key Methods

  • Electron microscopy
  • Electrophysiology
  • Fluorescence imaging
  • Genetically encoded reporters of synapse structure and function
  • In vivo 2-photon imaging
  • Opto- and chemo-genetics

Biography

Professor Burrone’s research aims to understand how neurons in the brain wire up to form functional circuits that remain stable over time. This work can contribute to a broad understanding of neurodevelopmental disorders, such as epilepsy, autism, and schizophrenia. Professor Burrone’s group is particularly interested in uncovering the rules that allow neurons to form synapses with each other during brain development, as well as the mechanisms employed to stabilise brain activity during this highly dynamic period. The group has recently begun to explore these rules in human neurons, particularly in the context of neurodevelopmental forms of epilepsy.

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